“Boosting Immune Cells with Food: Expert Insights”

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LISTEN | Exclusive interview with Greg Delgoffe, an immunologist at the University of Pittsburgh and the UPMC Hillman Cancer Center:

A recent discovery reveals that specific T-cells, a type of white blood cells, exhibit enhanced functionality post-meal consumption.

Describing T-cells as a vigilant army targeting viruses, bacteria, or precancerous cells within the body, Greg Delgoffe, an immunologist associated with the University of Pittsburgh and the UPMC Hillman Cancer Center, emphasized the significance of nutrition in combating infections.

Documented in April in the journal Nature, the study signifies the crucial role of eating in bolstering the immune response, potentially aiding in the enhancement of immune therapies and the optimization of vaccination schedules.

Delgoffe, a key contributor to the research, drew a parallel to Napoleon’s military strategy, highlighting the necessity of nourishing troops, which aligns with the study’s findings on the immune system.

a drawing of Napoleon Bonaparte leading his army in Italy in 1796 during the Revolutionary Wars.
Functioning akin to an army, white blood cells are primed to combat viruses and bacteria. An illustration portrays Napoleon Bonaparte leading his troops in Italy in 1798, as depicted by Pollet from an original painting by Ary Scheffer. (Hulton Archive/Getty Images)

Comparing Fasted T-cells and Fed T-cells

In a study conducted by researchers, blood samples were collected from 31 healthy volunteers twice in a day: first in the morning following an overnight fast, and later in the day after a meal. Post-meal intake, T-cells exhibited improved absorption of fats and sugars, along with enhanced energy production from mitochondria, showcasing the tangible impact of a meal.

Further experiments on mice demonstrated that fed mice generated more memory cells, a specialized subset of T-cells recognizing previously encountered pathogens like viruses or bacteria.

Maintaining a balanced diet is crucial for overall health, whether combating a common cold or cancer.– Russell Jones, chair of metabolism and nutritional programming at Van Andel Institute

Upon activation by foreign invaders such as viruses or bacteria, T-cells undergo rapid growth and division to form a widespread defense network in the body, demanding significant metabolic resources and explaining the fatigue experienced during illness, as per Delgoffe.

While acknowledging the lack of dietary control in their study, Delgoffe emphasized the consistent post-meal effects on T-cells, irrespective of participants’ meal compositions, highlighting the substantial benefits of a balanced diet.

a man in a white shirt smiles at the camera
Russell Jones, from the Van Andel Institute, explores cellular

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